Digranes A, Ostervold B, Madsen S T, Solberg C O, Haeger K
J Int Med Res. 1978;6(5):409-13. doi: 10.1177/030006057800600511.
Netilmicin, a semisynthetic derivative of sisomicin, was tested against 327 isolates of Staphylococcus aureus, Pseudomonas aeruginosa and Gram-negative enteric bacilli. Seventy-two per cent of the isolates were inhibited at a concentration of 0.5 microgram netilmicin per ml, and 93% of the isolates were susceptible to 4 microgram per ml or less. The MICs of netilmicin and gentamicin for 24 Providencia and 38 Pseudomonas isolates were compared. The activity of netilmicin closely paralleled that of gentamicin, 46% of the Providencia isolates and 32% of the Pseudomonas isolates not being inhibited by 4 microgram per ml of either drug.
奈替米星是西索米星的半合成衍生物，对327株金黄色葡萄球菌、铜绿假单胞菌和革兰氏阴性肠道杆菌进行了测试。72%的分离株在每毫升含0.5微克奈替米星的浓度下受到抑制，93%的分离株对每毫升4微克或更低浓度敏感。比较了奈替米星和庆大霉素对24株普罗威登斯菌和38株铜绿假单胞菌分离株的最低抑菌浓度。奈替米星的活性与庆大霉素密切相似，每毫升4微克的任何一种药物均未抑制46%的普罗威登斯菌分离株和32%的铜绿假单胞菌分离株。
