Briedis D J, Robson H G
Antimicrob Agents Chemother. 1976 Oct;10(4):592-7. doi: 10.1128/AAC.10.4.592.
Netilmicin (Sch 20569), a semisynthetic aminoglycoside antibiotic, was compared with gentamicin, tobramycin, and amikacin against 242 clinical isolates of Pseudomonas and Enterobacteriaceae. The minimum inhibitory concentration (MIC) was determined in both solid and liquid media. Netilmicin exhibited typical aminoglycoside properties, such as little effect of inoculum size on MIC, relatively small gap between MIC and minimum bactericidal concentration, and potentiation of anti-Pseudomonas activity in the presence of carbenicillin. Netilmicin provided no advantage in antimicrobial activity over gentamicin for either Pseudomonas or Enterobacteriaceae. Nearly complete cross-resistance to netilmicin was encountered with isolates resistant to gentamicin in either solid or liquid media. Netilmicin was less active than gentamicin against isolates of Pseudomonas and Providencia. Major discrepancies between MIC values determined in agar as opposed to those determined in broth were encountered for most isolates of Pseudomonas but also, depending upon antibiotic tested, for between 15 and 40% of isolates of Enterobacteriaceae. This new aminoglycoside agent will be useful clinically only if it is shown to be significantly less toxic than presently available analogues.
奈替米星（Sch 20569），一种半合成氨基糖苷类抗生素，与庆大霉素、妥布霉素和阿米卡星针对242株铜绿假单胞菌和肠杆菌科临床分离株进行了比较。在固体和液体培养基中均测定了最低抑菌浓度（MIC）。奈替米星表现出典型的氨基糖苷类特性，如接种量大小对MIC影响较小、MIC与最低杀菌浓度之间差距相对较小，以及在羧苄青霉素存在下抗铜绿假单胞菌活性增强。对于铜绿假单胞菌或肠杆菌科，奈替米星在抗菌活性方面相对于庆大霉素并无优势。在固体或液体培养基中，对庆大霉素耐药的分离株对奈替米星几乎完全交叉耐药。奈替米星对铜绿假单胞菌和普罗威登斯菌分离株的活性低于庆大霉素。对于大多数铜绿假单胞菌分离株，以及取决于所测试的抗生素，肠杆菌科15%至40%的分离株，在琼脂中测定的MIC值与在肉汤中测定的MIC值之间存在重大差异。只有当这种新的氨基糖苷类药物被证明毒性明显低于现有类似物时，它在临床上才会有用。
