庆大霉素耐药肠杆菌科细菌和铜绿假单胞菌对奈替米星及选定氨基糖苷类抗生素的体外敏感性
In vitro susceptibility of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa to netilmicin and selected aminoglycoside antibiotics.
作者信息
Meyer R D, Draus L L, Pasieczinik K A
出版信息
Antimicrob Agents Chemother. 1976 Oct;10(4):677-81. doi: 10.1128/AAC.10.4.677.
Abstract
Netilmicin (Sch 20569), a semisynthetic aminoglycoside related to gentamicin C(1a), was evaluated in vitro in agar dilution testing against 224 different clinical isolates of gentamicin-resistant Enterobacteriaceae and Pseudomonas aeruginosa in parallel with amikacin, gentamicin, sisomicin, and tobramycin. Netilmicin showed a very high degree of activity against gentamicin-resistant organisms, but amikacin was more active in vitro, particularly against Providencia stuartii and P. aeruginosa. Sisomicin and tobramycin were consistently less active than either netilmicin or amikacin. Netilmicin was bactericidal in broth testing against P. aeruginosa. Netilmicin showed a greater difference between results with agar and broth dilution testing than did amikacin.
摘要
奈替米星（Sch 20569）是一种与庆大霉素C(1a)相关的半合成氨基糖苷类抗生素，在琼脂稀释试验中进行了体外评估，以检测其对224株不同的耐庆大霉素肠杆菌科细菌和铜绿假单胞菌临床分离株的活性，同时与阿米卡星、庆大霉素、西索米星和妥布霉素进行比较。奈替米星对耐庆大霉素的微生物显示出非常高的活性，但阿米卡星在体外更具活性，尤其是对斯氏普罗威登斯菌和铜绿假单胞菌。西索米星和妥布霉素的活性始终低于奈替米星或阿米卡星。在肉汤试验中，奈替米星对铜绿假单胞菌具有杀菌作用。与阿米卡星相比，奈替米星在琼脂和肉汤稀释试验结果之间的差异更大。
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