阿霉素诱导的兔心肌病中心肌线粒体的功能
Function of myocardial mitochondria in the adriamycin-induced cardiomyopathy of rabbits.
作者信息
Bier C C, Jaenke R S
出版信息
J Natl Cancer Inst. 1976 Nov;57(5):1091-4. doi: 10.1093/jnci/57.5.1091.
PMID:1003544
Abstract
Ultrastructural examination of the myocardia of New Zealand White rabbits showed a progressive cardiomyopathy with prominent mitochondrial lesions after 56 days of increased doses of adriamycin. During all phases of study, similar respiratory control rates and ADP:O ratios were found in myocardial mitochondria isolated from adriamycin-treated and control rabbits.
摘要
对新西兰白兔心肌进行的超微结构检查显示，在增加阿霉素剂量56天后出现了进行性心肌病，并伴有明显的线粒体损伤。在研究的所有阶段，从阿霉素处理组和对照组兔子分离出的心肌线粒体中，发现了相似的呼吸控制率和ADP:O比率。
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