阿霉素诱导的兔心肌病中心肌线粒体的功能

Function of myocardial mitochondria in the adriamycin-induced cardiomyopathy of rabbits.

作者信息

Bier C C, Jaenke R S

出版信息

J Natl Cancer Inst. 1976 Nov;57(5):1091-4. doi: 10.1093/jnci/57.5.1091.

DOI:10.1093/jnci/57.5.1091

Abstract

Ultrastructural examination of the myocardia of New Zealand White rabbits showed a progressive cardiomyopathy with prominent mitochondrial lesions after 56 days of increased doses of adriamycin. During all phases of study, similar respiratory control rates and ADP:O ratios were found in myocardial mitochondria isolated from adriamycin-treated and control rabbits.

摘要

对新西兰白兔心肌进行的超微结构检查显示，在增加阿霉素剂量56天后出现了进行性心肌病，并伴有明显的线粒体损伤。在研究的所有阶段，从阿霉素处理组和对照组兔子分离出的心肌线粒体中，发现了相似的呼吸控制率和ADP:O比率。