Department of Pharmacology, K.L.E. Society's College of Pharmacy, Hubli, India.
Indian J Pharmacol. 2012 Jan;44(1):73-7. doi: 10.4103/0253-7613.91871.
To study the preventive role of curcumin against doxorubicin (Dox)-induced myocardial toxicity in rats.
Cardiotoxicity was produced by cumulative administration of Dox (15 mg/kg for two weeks). Curcumin (200 mg/kg, po) was administered as pretreatment for two weeks and then for two alternate weeks with Dox. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after three weeks of last dose.
The repeated administration of Dox induced cardiomyopathy associated with an antioxidant deficit and increased level biomarkers. Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal. Curcumin increased the reduced level of GSH, SOD and CAT and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue.
The biochemical and histopathology reports support the cardioprotective effect of curcumin which could be attributed to antioxidant.
研究姜黄素对阿霉素（Dox）诱导的大鼠心肌毒性的预防作用。
通过累积给予阿霉素（15mg/kg，连续两周）来产生心脏毒性。姜黄素（200mg/kg，po）作为预处理，连续两周，然后与阿霉素交替两周。在最后一次给药三周后，观察一般情况、死亡率、组织病理学、乳酸脱氢酶（LDH）和肌酸磷酸激酶（CPK）等生物标志物酶、天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和碱性磷酸酶（ALP）等生化参数、谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）等抗氧化酶。
阿霉素的重复给予导致与抗氧化缺陷和生物标志物水平升高相关的心肌病。姜黄素预处理可通过降低 LDH 和 CPK 等生物标志物酶以及 AST、ALT 和 ALP 等生化参数的升高水平，显著保护心肌免受 Dox 的毒性作用。姜黄素增加了 GSH、SOD 和 CAT 的还原水平，降低了心脏组织中丙二醛（MDA）的升高水平。
生化和组织病理学报告支持姜黄素的心脏保护作用，这可能归因于抗氧化作用。
