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吡咯菌素的抗皮肤癣菌活性及皮肤组织浓度

Antitrichophyton activity and dermal tissue concentration of pyrrolnitrin.

作者信息

Kamimura T, Nishida M

出版信息

Jpn J Antibiot. 1976 Nov;29(11):1003-6.

PMID:1003677
Abstract

Though pyrrolnitrin is surpassed by clotrimazole in in vitro antitrichophyton activity against Trichophyton sp., the therapeutic effect of pyrrolnitrin against experimental trichophytosis in guinea pigs was more potent than that of clotrimazole. The detection of antifungal activity from topically treated guinea pigs suggests that pyrrolnitrin obtains higher concentrations than clotrimazole in dermal tissue.

摘要

尽管在体外对毛癣菌属的抗皮肤真菌活性方面，吡咯尼群被克霉唑超越，但吡咯尼群对豚鼠实验性皮肤癣菌病的治疗效果比克霉唑更强。对局部治疗的豚鼠进行抗真菌活性检测表明，吡咯尼群在皮肤组织中获得的浓度高于克霉唑。

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