Efficacy of 6-amino-2-n-pentylthiobenzothiazole on Trichophyton in vitro and in vivo.

In vitro and in vivo antifungal activities of synthetically parepared 6-amino-2-n-pentylthiobenzothiazole (APB) against Trichophyton strains were studied. APB inhibited the growth of 3 Trichophyton strains at 65 micrograms/ml. 2-Mercaptobenzothiazole was not effective at 125 micrograms/ml and ketoconazole inhibited the growth at 20-30 micrograms/ml. Treatment of experimental dermatophytosis in guinea pigs using 2.5% APB cream was studied in comparison to Canesten cream (1% clotrimazole). Dermatophytosis was considerably reduced after both APB and Canesten therapies.