Fordice J, Kershaw C, El-Naggar A, Goepfert H
Department of Head and Neck Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030-4662, USA.
Arch Otolaryngol Head Neck Surg. 1999 Feb;125(2):149-52. doi: 10.1001/archotol.125.2.149.
To review 160 patients treated at a single institution for adenoid cystic carcinoma during the 20 years between 1977 and 1996, applying a consistent treatment of surgery and postoperative radiation therapy to 140 patients. To analyze factors governing treatment failure, treatment-related morbidity, and mortality.
Retrospective review.
Tertiary referral center.
Seventy-seven males and 83 females aged 13 to 89 years (average age, 49.5 years).
Combined treatment yielded an 85% locoregional freedom from relapse and disease-specific survival at 5, 10, and 15 years was 89%, 67.4%, and 39.6%, respectively. Thirty-five patients (21.9%) had distant metastases as the only site of failure. Patients treated for paranasal sinus tumor experienced the most treatment-related morbidity vs other sites. Perineural invasion of major nerves, positive margins at surgery, and solid histological features were associated with increased treatment failures. Four or more symptoms present at diagnosis, positive lymph nodes, solid histology, and perineural invasion of major nerves were associated with increased mortality from disease.
回顾1977年至1996年20年间在单一机构接受治疗的160例腺样囊性癌患者，其中140例患者接受了一致的手术及术后放射治疗。分析影响治疗失败、治疗相关发病率和死亡率的因素。
回顾性研究。
三级转诊中心。
77例男性和83例女性，年龄13至89岁（平均年龄49.5岁）。
联合治疗使局部区域复发率为85%，5年、10年和15年的疾病特异性生存率分别为89%、67.4%和39.6%。35例患者（21.9%）仅远处转移为失败部位。与其他部位相比，接受鼻窦肿瘤治疗的患者出现的治疗相关发病率最高。主要神经的神经周围侵犯、手术切缘阳性以及实性组织学特征与治疗失败增加相关。诊断时出现四种或更多症状、阳性淋巴结、实性组织学以及主要神经的神经周围侵犯与疾病死亡率增加相关。
