Chan H H, King W W, Chan E S, Mok C O, Ho W S, Van Krevel C, Lau W Y
Department of Medicine and Therapeutics, Chinese University of Hong Kong, Shatin, Republic of China.
Lasers Surg Med. 1999;24(1):24-8. doi: 10.1002/(sici)1096-9101(1999)24:1<24::aid-lsm5>3.0.co;2-z.
Different types of Q-switched lasers have been found to be effective in the treatment of nevus of Ota. However, a clinical trial involving in vivo comparison of the use of different laser systems has not been performed. The aim of the present study was to compare the patient tolerance of Q-switched Alexandrite (QS Alex) and Q-switched neodymium:yttrium-aluminum-garnet (QS Nd:YAG) lasers in the treatment of nevus of Ota.
STUDY DESIGN/MATERIALS AND METHODS: Thirty-three patients (11 male, 22 female) were recruited for this study, and 45 treatment sessions were performed. Half of each lesion was treated with QS Alex and the other half with QS Nd:YAG laser. Patients were interviewed with a visual analog scale questionnaire immediately after treatment and 1 week later. Questions included the degree of pain, swelling, and bleeding.
The immediate pain after treatment was more severe for QS Alex than for QS Nd:YAG laser. However, 1 week after laser therapy, most patients found QS Alex to be superior.
Patients tolerate QS-Alex better than QS Nd:YAG. This finding is important because patients with nevus of Ota are often children, and multiple laser sessions are necessary for complete resolution of the lesion.
已发现不同类型的调Q激光对太田痣的治疗有效。然而，尚未进行一项涉及不同激光系统体内使用比较的临床试验。本研究的目的是比较调Q紫翠宝石（QS Alex）激光和调Q钕：钇铝石榴石（QS Nd:YAG）激光治疗太田痣时患者的耐受性。
研究设计/材料与方法：本研究招募了33名患者（11名男性，22名女性），共进行了45次治疗。每个皮损的一半用QS Alex激光治疗，另一半用QS Nd:YAG激光治疗。治疗后立即和1周后，用视觉模拟量表问卷对患者进行访谈。问题包括疼痛、肿胀和出血程度。
治疗后即刻，QS Alex激光引起的疼痛比QS Nd:YAG激光更严重。然而，激光治疗1周后，大多数患者发现QS Alex激光更优。
患者对QS Alex激光的耐受性优于QS Nd:YAG激光。这一发现很重要，因为太田痣患者通常是儿童，且为完全清除皮损需要多次激光治疗。
