不育男性患睾丸癌的风险：病例对照研究。
Risk of testicular cancer in subfertile men: case-control study.
作者信息
Møller H, Skakkebaek N E
机构信息
Centre for Research in Health and Social Statistics, Danish National Research Foundation, Sejrogade 11, DK-2100 Copenhagen O, Denmark.
出版信息
BMJ. 1999 Feb 27;318(7183):559-62. doi: 10.1136/bmj.318.7183.559.
OBJECTIVE
To evaluate the association between subfertility in men and the subsequent risk of testicular cancer.
DESIGN
Population based case-control study.
SETTING
The Danish population.
PARTICIPANTS
Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated.
OUTCOME MEASURE
Occurrence of testicular cancer.
RESULTS
A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors.
CONCLUSION
These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.
目的
评估男性生育力低下与随后患睾丸癌风险之间的关联。
设计
基于人群的病例对照研究。
地点
丹麦人群。
参与者
病例来自丹麦癌症登记处；对照从丹麦人口中通过计算机化的丹麦中央人口登记册随机选取。通过电话对男性进行访谈；514名患癌男性和720名对照参与。
观察指标
睾丸癌的发生情况。
结果
生育与睾丸癌风险降低相关（相对风险0.63；95%置信区间0.47至0.85）。在诊断为睾丸癌之前孩子数量低于基于其年龄预期数量的男性中，相对风险为1.98（1.43至2.75）。孩子数量高于预期数量则无相应的保护作用。精原细胞瘤和非精原细胞瘤的关联相似，且不受潜在混杂因素调整的影响。
结论
这些数据与男性生育力低下和睾丸癌有重要病因学因素相同这一假设一致。
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