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[圣犹达医疗人工心脏瓣膜用于小主动脉瓣环患者的血流动力学评估]

[Hemodynamic evaluations of patients with small aortic annulus with St. Jude Medical prosthetic heart valve].

作者信息

Shimabukuro T, Takeuchi Y, Gomi A, Nakatani H, Suda Y, Kono K, Nagano N

机构信息

Department of Cardiovascular Surgery, Kanto Teishin Hospital, Tokyo, Japan.

出版信息

Jpn J Thorac Cardiovasc Surg. 1998 Dec;46(12):1285-91. doi: 10.1007/BF03217917.

Abstract

As the elderly population in Japan increases, senile degenerative aortic valvular disease also tends to increase. These patients often have a small aortic annulus. The problem of "valve-patient-mismatch" occurs when a small prosthesis is inserted into a patient with a small aortic annulus. To avoid annular enlargement after aortic valve replacement (AVR), we tried to use a small-sized St. Jude Medical (SJM) valve. From September 1988 through November 1996, 110 AVR were performed in our institution. In these cases, 30 underwent AVR with a small sized SJM valve (male < or = 21 mm, female < or = 19 mm). Dobutamine stress echocardiography was performed in 19 patients who had undergone AVR with a small-sized SJM valve. Surgical results were also compared between patients with small aortic annulus and those with normal-sized aortic annulus. Using Doppler echocardiography, pressure gradients (PG), cardiac index (CI), effective orifice area (EOA), and performance index (PI) were calculated at rest and during stress. The mean body surface area (BSA) of patient who had undergone AVR with SJM19A, 19HP and 21A was 1.40, 1.42 and 1.56 m2, respectively. With dobutamine stress, heart rates, PG and CI increased significantly. Mean and maximum PG of patients with 19HP (8.0 and 15.4 mmHg at rest, 12.9 and 28.0 mmHg under stress, respectively) and 21A (9.5 and 19.1 mmHg at rest, 16.5 and 35.3 mmHg under stress, respectively) were relatively low. EOA index (EOAI) of patient with 19HP showed the highest values mean 0.93 cm2/m2. PIs tended to be higher with HP models than with standard models. The tests were completed without significant side effects such as frequent ventricular arrhythmias. Among the cases with small aortic annulus, there were no operative deaths or hospital deaths. There were also no late deaths, episodes of hemorrhage or thrombosis. Conclusions. In our institution, AVR was performed safely without any aortic annular enlargement with a small aortic anulus in small BSA patients. Postoperative hemodynamic data obtained by echocardiography were satisfactory for all patients at rest and even during maximum dobutamine stress test.

摘要

随着日本老年人口的增加,老年性退行性主动脉瓣疾病也有增加的趋势。这些患者的主动脉瓣环往往较小。当将小号人工瓣膜植入主动脉瓣环较小的患者体内时,就会出现“瓣膜-患者不匹配”的问题。为避免主动脉瓣置换术(AVR)后瓣环扩大,我们尝试使用小号的圣犹达医疗(SJM)瓣膜。从1988年9月至1996年11月,我们机构共进行了110例AVR手术。在这些病例中,30例使用小号SJM瓣膜进行了AVR手术(男性≤21mm,女性≤19mm)。对19例接受小号SJM瓣膜AVR手术的患者进行了多巴酚丁胺负荷超声心动图检查。还比较了主动脉瓣环较小的患者与主动脉瓣环大小正常的患者的手术结果。使用多普勒超声心动图,计算静息和负荷状态下的压力阶差(PG)、心脏指数(CI)、有效瓣口面积(EOA)和性能指数(PI)。接受SJM19A、19HP和21A瓣膜AVR手术患者的平均体表面积(BSA)分别为1.40、1.42和1.56m²。在多巴酚丁胺负荷状态下,心率、PG和CI显著增加。19HP瓣膜患者(静息时平均PG和最大PG分别为8.0和15.4mmHg,负荷时分别为12.9和28.0mmHg)和21A瓣膜患者(静息时分别为9.5和19.1mmHg,负荷时分别为16.5和35.3mmHg)的平均PG和最大PG相对较低。19HP瓣膜患者的EOA指数(EOAI)均值最高,为0.93cm²/m²。HP型号的PI往往高于标准型号。检查完成时未出现明显副作用,如频繁室性心律失常。在主动脉瓣环较小的病例中,无手术死亡或住院死亡。也无晚期死亡、出血或血栓形成事件。结论。在我们机构,对于体表面积小且主动脉瓣环小的患者,AVR手术安全进行,未出现任何主动脉瓣环扩大。通过超声心动图获得的术后血流动力学数据在静息状态下以及甚至在最大多巴酚丁胺负荷试验期间对所有患者来说都是令人满意的。

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