Tenner A J
Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697-3900, USA.
Curr Opin Immunol. 1999 Feb;11(1):34-41. doi: 10.1016/s0952-7915(99)80007-7.
Membrane receptors for the soluble 'defense collagens' - naturally occurring chimeric molecules that contain a recognition domain contiguous with a collagen-like triple helical domain and play a role in protecting the host from pathogens entering the blood, lung and other tissues - are being isolated. These receptors are key to understanding the mechanisms by which defense collagens influence cellular responses in order to either provide rapid 'stealth clearance' of cellular debris or to initiate the responses that lead to the destruction of harmful microbes.
可溶性“防御胶原蛋白”的膜受体正在被分离出来。“防御胶原蛋白”是天然存在的嵌合分子，其包含与胶原样三螺旋结构域相邻的识别结构域，并在保护宿主免受病原体进入血液、肺部和其他组织方面发挥作用。这些受体对于理解防御胶原蛋白影响细胞反应的机制至关重要，这些机制要么用于对细胞碎片进行快速的“隐形清除”，要么引发导致有害微生物破坏的反应。
