O'Reilly M, Teichmann S A, Rhodes D
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
Curr Opin Struct Biol. 1999 Feb;9(1):56-65. doi: 10.1016/s0959-440x(99)80008-6.
Telomerases are RNA-dependent polymerases that catalyse the synthesis of the telomeric DNA at the tips of eukaryotic chromosomes. The recent identification of the catalytic subunit of telomerases from several different species suggests that the core of the telomerase is conserved. The proposed sequence and structural homology between the telomerase catalytic subunit and reverse transcriptases, together with a wealth of genetic and biochemical information, has led to significant advances in our understanding of the mechanism by which telomerases synthesise telomeric DNA.
端粒酶是一种依赖RNA的聚合酶，可催化真核染色体末端端粒DNA的合成。最近从几种不同物种中鉴定出端粒酶的催化亚基，这表明端粒酶的核心是保守的。端粒酶催化亚基与逆转录酶之间推测的序列和结构同源性，以及大量的遗传和生化信息，使我们对端粒酶合成端粒DNA的机制的理解取得了重大进展。
