Rao V, Christakis G T, Sever J, Fremes S E, Bhatnagar G, Cohen G, Borger M A, Abouzahr L, Goldman B S
Division of Cardiovascular Surgery, Sunnybrook Health Science Centre; University of Toronto, Toronto, Ontario, Canada.
J Thorac Cardiovasc Surg. 1999 Mar;117(3):431-6; discussion 436-38. doi: 10.1016/s0022-5223(99)70321-1.
Previous studies have compared prosthetic valves on the basis of industry-labeled valve sizes. Unfortunately, the relationship between the labeled size and the true measured external or internal diameter differs between valve manufacturers. Therefore hemodynamic comparisons between prosthetic valves are inaccurate if based solely on industry-labeled valve sizes.
We have previously demonstrated that the internal diameter of a 21-mm Carpentier-Edwards pericardial stented valve is similar to that of a 25-mm Toronto stentless porcine valve. Therefore we chose to compare postoperative hemodynamics in patients who received 19-, 21-, or 23-mm Carpentier-Edwards pericardial stented valves (inner diameter 18-22 mm, n = 69) with those in patients who received 23- or 25-mm stentless porcine valves (internal diameter 19-21 mm, n = 41).
Patients in the Carpentier-Edwards group were more likely to be elderly and more likely to require concomitant revascularization. Operative mortality was lower in the stentless porcine valve group (0% vs 9%, P =.06). Hospital stay and ventilation requirements were shorter in the stentless porcine valve group. Postoperative hemodynamics were similar in the two groups.
These data provide evidence that stentless and stented valves have similar hemodynamic profiles in the small aortic root when matched on true measured internal diameters. The clinical benefit of the stentless porcine valve may be due to patient selection or the lack of a rigid stent in the small aortic root, but it is not due to hemodynamic superiority over stented aortic valves of similar sizes.
既往研究基于瓣膜制造商标注的瓣膜尺寸对人工瓣膜进行比较。遗憾的是,不同瓣膜制造商的标注尺寸与实际测量的外径或内径之间的关系有所不同。因此,仅基于制造商标注的瓣膜尺寸对人工瓣膜进行血流动力学比较是不准确的。
我们之前已经证明,21毫米Carpentier-Edwards心包带支架瓣膜的内径与25毫米多伦多无支架猪瓣膜的内径相似。因此,我们选择比较接受19毫米、21毫米或23毫米Carpentier-Edwards心包带支架瓣膜(内径18 - 22毫米,n = 69)的患者与接受23毫米或25毫米无支架猪瓣膜(内径19 - 21毫米,n = 41)的患者术后的血流动力学情况。
Carpentier-Edwards组的患者更可能为老年人,且更可能需要同时进行血管重建。无支架猪瓣膜组的手术死亡率较低(0%对9%,P = 0.06)。无支架猪瓣膜组的住院时间和通气需求更短。两组术后的血流动力学情况相似。
这些数据表明,当根据实际测量的内径进行匹配时,无支架瓣膜和带支架瓣膜在小主动脉根部具有相似的血流动力学特征。无支架猪瓣膜的临床益处可能归因于患者选择或小主动脉根部缺乏刚性支架,但并非因其血流动力学优于类似尺寸的带支架主动脉瓣膜。