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老年患者使用无支架或带支架主动脉瓣植入物?

Stentless or stented aortic valve implants in elderly patients?

作者信息

Van Nooten G, Caes F, François K, Van Belleghem Y, Taeymans Y

机构信息

Cardiac Surgery Department, University Hospital Gent, Ghent, Belgium.

出版信息

Eur J Cardiothorac Surg. 1999 Jan;15(1):31-6. doi: 10.1016/s1010-7940(98)00288-7.

Abstract

OBJECTIVE

To assess differences in indication and mid-term results between stentless and stented procedures in elderly patients, we followed aortic valve patients over a period of 5 years.

METHODS

In a consecutive series of 154 elderly aortic patients in regular sinus rhythm from 1992 to 1997, we inserted 103 stentless (Toronto SPVTM, St Jude Medical Inc., St Paul, Minneapolis, MN) and 51 stented (Carpentier-Edwards supra annular porcine, Baxter Inc., Irvine, CA) bioprostheses in the aortic position.

RESULTS

All 154 patients seemed preoperatively eligible for a stentless procedure. Mean age was 74.8 years (range 67-86 years) with a majority of female patients. The surgeon's (in)experience, major dilatation or calcifications of the ascending aorta and aberrant coronary anatomy were the most common reasons for drawback from the stentless procedure (51/154 patients). Aortic clamp time was significantly higher in the stentless vs. stented group (70 vs. 57 min, P < 0.0001). The large average 25.3 mm size of the stentless prostheses (vs. 23.7 mm stented) stands in full contrast with the low mean body surface area of 1.68 m2 (vs. 1.70 m2) of the patients. We encountered. respectively. 5 and 2 hospital-deaths (P = n.s.). The follow-up period ranged from 6 to 66 months and was 97% complete, yielding, respectively, 302 and 139 patient-years. Survival (Kaplan-Meier method) was statistically higher in favor of the stentless procedures (log rank: P = 0.03). All survivors progressed markedly to a mean postoperative NYHA class 1.3 respectively, 1.4 (vs. preop. 3.3 and 3.2). Echocardiographic transvalvular gradients compared favorable for the stentless group in the small under 25 mm valves (P = 0.02 for 23 mm sized valves between groups) with improved left ventricular function and a significant decrease of left ventricular end diastolic diameter (LVEDD 48.0 vs. 56.5 mm) at 1 year follow-up. Cusp calcifications on control echocardiography were detected earlier (beyond 3 years) in the stented group, without signs of early significant regurgitation or dysfunction in both groups, except for one patient necessitating re-operation.

CONCLUSION

Although the implantation technique is much more demanding for stentless procedures, reflected by a longer aortic clamp-time, and remains impossible in some cases, elderly, small sized patients take full benefit of their large, non-obstructive prostheses.

摘要

目的

为评估老年患者无支架与有支架手术在适应证和中期结果方面的差异,我们对主动脉瓣患者进行了为期5年的随访。

方法

在1992年至1997年间连续纳入的154例窦性心律正常的老年主动脉瓣患者中,我们在主动脉位置植入了103个无支架生物假体(多伦多SPVTM,圣犹达医疗公司,明尼苏达州圣保罗)和51个有支架生物假体(卡朋蒂埃-爱德华兹超环上猪生物瓣,百特公司,加利福尼亚州欧文)。

结果

所有154例患者术前似乎都适合进行无支架手术。平均年龄为74.8岁(范围67 - 86岁),女性患者居多。外科医生的经验、升主动脉的严重扩张或钙化以及冠状动脉解剖异常是放弃无支架手术的最常见原因(51/154例患者)。无支架组的主动脉阻断时间显著长于有支架组(70分钟对57分钟,P < 0.0001)。无支架假体的平均尺寸较大,为25.3毫米(相比之下有支架的为23.7毫米),这与患者较低的平均体表面积1.68平方米(相比之下有支架组为1.70平方米)形成鲜明对比。我们分别遇到5例和2例医院死亡(P = 无显著差异)。随访期为6至66个月,完成率为97%,分别产生302和139患者年。生存率(Kaplan-Meier法)在统计学上更有利于无支架手术(对数秩检验:P = 0.03)。所有幸存者术后NYHA分级均显著改善,分别为平均1.3级和1.4级(术前为3.3级和3.2级)。在小于25毫米的小瓣膜中,无支架组的超声心动图跨瓣压差更有利(23毫米尺寸瓣膜组间P = 0.02),左心室功能改善,随访1年时左心室舒张末期内径显著减小(48.0毫米对56.5毫米)。在有支架组中,超声心动图复查时更早(超过3年)检测到瓣叶钙化,两组均无早期明显反流或功能障碍的迹象,但有1例患者需要再次手术。

结论

尽管无支架手术的植入技术要求更高,表现为主动脉阻断时间更长,且在某些情况下仍无法进行,但老年、体型较小的患者充分受益于其大型、无阻塞的假体。

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