Nakashima M, Aoyagi T, Aratake K, Kawabe Y, Eguchi K
Department of Internal Medicine, Ureshino National Hospital.
Ryumachi. 1998 Dec;38(6):793-800.
We studied the relationship of FDP and D-dimer levels of rheumatoid arthritis (RA) patients with their activities of RA. We evaluated FDP/D-dimer levels of thirty-six RA patients. And we also evaluated FDP/D-dimer levels of 14 patients with systemic lupus erythematosus (SLE) and 12 patients with other rheumatic diseases as control. RA patients were divided into two groups according to their activities. Nineteen patients, who fulfilled at least three of four activities criteria, were classified as active group [RA (A) group], and other 17 patients were classified as not-active group [RA (B) group]. FDP and D-dimer levels of RA patients were higher than those of SLE or other patients group significantly (P < 0.01). Furthermore, in RA patients, high levels of FDP and D-dimer were observed in RA (A) group compared to RA (B) group. In some RA patients, decrease of FDP and D-dimer levels were observed according to their RA activities. FDP and D-dimer levels were not correlated with the level of rheumatoid factor (RF). These results show that the FDP and D-dimer levels were elevated according to RA activity in RA patients.
我们研究了类风湿关节炎（RA）患者的纤维蛋白降解产物（FDP）和D - 二聚体水平与其RA活动度之间的关系。我们评估了36例RA患者的FDP/D - 二聚体水平。并且我们还评估了14例系统性红斑狼疮（SLE）患者和12例其他风湿性疾病患者作为对照的FDP/D - 二聚体水平。RA患者根据其活动度分为两组。19例至少满足四项活动标准中的三项的患者被分类为活动组[RA（A）组]，另外17例患者被分类为非活动组[RA（B）组]。RA患者的FDP和D - 二聚体水平显著高于SLE患者或其他患者组（P < 0.01）。此外，在RA患者中，与RA（B）组相比，RA（A）组观察到高水平的FDP和D - 二聚体。在一些RA患者中，根据其RA活动度观察到FDP和D - 二聚体水平降低。FDP和D - 二聚体水平与类风湿因子（RF）水平无关。这些结果表明，RA患者的FDP和D - 二聚体水平根据RA活动度而升高。
