Chen F S, Frenkel S R, Di Cesare P E
Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
Am J Orthop (Belle Mead NJ). 1999 Jan;28(1):31-3.
Articular cartilage injuries result in numerous clinical symptoms, such as pain and decreased functional levels. The limited reparative capabilities of hyaline cartilage results in the generation of repair tissue that lacks the structure and biomechanical properties of normal cartilage. Chondrocytes are unable to adequately proliferate, migrate, and synthesize high-quality repair tissue in response to blunt, superficial, or deep penetrating trauma. Extensive research has been conducted to understand the healing process and devise techniques that would enhance this response. Part I of this paper will discuss the basic science of cartilage repair. Part II, which will be published in the February issue, will present the treatment options.
关节软骨损伤会导致多种临床症状，如疼痛和功能水平下降。透明软骨有限的修复能力导致生成的修复组织缺乏正常软骨的结构和生物力学特性。软骨细胞在受到钝性、浅表或深度穿透性创伤时，无法充分增殖、迁移并合成高质量的修复组织。人们已经进行了广泛的研究，以了解愈合过程并设计出能够增强这种反应的技术。本文的第一部分将讨论软骨修复的基础科学。第二部分将发表在二月刊上，将介绍治疗选择。
