用于软骨修复的生物制剂控释策略。
Strategies for controlled delivery of biologics for cartilage repair.
作者信息
Lam Johnny, Lu Steven, Kasper F Kurtis, Mikos Antonios G
机构信息
Department of Bioengineering, Rice University, Houston, TX, United States.
Department of Bioengineering, Rice University, Houston, TX, United States; Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, United States.
出版信息
Adv Drug Deliv Rev. 2015 Apr;84:123-34. doi: 10.1016/j.addr.2014.06.006. Epub 2014 Jun 30.
The delivery of biologics is an important component in the treatment of osteoarthritis and the functional restoration of articular cartilage. Numerous factors have been implicated in the cartilage repair process, but the uncontrolled delivery of these factors may not only reduce their full reparative potential but can also cause unwanted morphological effects. It is therefore imperative to consider the type of biologic to be delivered, the method of delivery, and the temporal as well as spatial presentation of the biologic to achieve the desired effect in cartilage repair. Additionally, the delivery of a single factor may not be sufficient in guiding neo-tissue formation, motivating recent research toward the delivery of multiple factors. This review will discuss the roles of various biologics involved in cartilage repair and the different methods of delivery for appropriate healing responses. A number of spatiotemporal strategies will then be emphasized for the controlled delivery of single and multiple bioactive factors in both in vitro and in vivo cartilage tissue engineering applications.
生物制剂的递送是骨关节炎治疗和关节软骨功能恢复的重要组成部分。软骨修复过程涉及众多因素，但这些因素的非控制性递送不仅可能降低其完全修复潜力，还可能导致不良的形态学效应。因此，必须考虑要递送的生物制剂类型、递送方法以及生物制剂的时间和空间呈现方式，以在软骨修复中实现预期效果。此外，单一因子的递送可能不足以引导新组织形成，这促使近期研究转向多种因子的递送。本综述将讨论参与软骨修复的各种生物制剂的作用以及为实现适当愈合反应的不同递送方法。然后将强调一些时空策略，用于在体外和体内软骨组织工程应用中对单一和多种生物活性因子进行控制性递送。
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