Chen F S, Frenkel S R, Di Cesare P E
Department of Orthopaedic Surgery, Hospital for Joint Diseases Orthopaedic Institute, New York, New York, USA.
Am J Orthop (Belle Mead NJ). 1999 Feb;28(2):88-96.
Articular cartilage injuries result in numerous clinical symptoms, such as pain and decreased functional levels. Current therapeutic options being used include articular surface debridement, such as chondral shaving, abrasion chondroplasty, and subchondral perforation; soft-tissue arthroplasties, such as perichondrial and periosteal grafts; and osteochondral transplantation. None of these therapies, however, has resulted in the successful regeneration of a hyaline-like tissue that withstands normal joint loading and activity over prolonged periods. As a result, research is also being conducted on alternative therapeutic procedures to enhance the repair process and to stimulate the regeneration of a repair tissue with hyaline-like structural and biologic properties. Part I of this paper, which was published in January, discussed the basic science of cartilage healing. Part II presents the treatment options.
关节软骨损伤会导致多种临床症状，如疼痛和功能水平下降。目前正在使用的治疗方法包括关节面清创术，如软骨刮削术、磨削软骨成形术和软骨下钻孔术；软组织关节成形术，如软骨膜和骨膜移植术；以及骨软骨移植术。然而，这些治疗方法均未成功再生出能长期承受正常关节负荷和活动的透明软骨样组织。因此，人们也在研究其他治疗方法，以促进修复过程，并刺激具有透明软骨样结构和生物学特性的修复组织再生。本文的第一部分于1月份发表，讨论了软骨愈合的基础科学。第二部分介绍了治疗选择。
