Lozano-Chiu M, Arikan S, Paetznick V L, Anaissie E J, Loebenberg D, Rex J H
Department of Internal Medicine, University of Texas Medical School, Houston 77030, USA.
Antimicrob Agents Chemother. 1999 Mar;43(3):589-91. doi: 10.1128/AAC.43.3.589.
Doses of 10 to 100 mg of the azole antifungal agent SCH 5692/kg of body weight/day were studied in immunocompetent mice as therapy for systemic infection by Fusarium solani. Treatment was begun 1 h after intravenous infection and continued daily for 4 or 13 doses. Prolongation of survival and organ clearance were dependent on both the dose and the duration of SCH 56592 therapy, with the best results seen at 50 and 100 mg/kg/day. The results at the highest doses of SCH 56592 used (50 or 100 mg/kg/day) were comparable to those obtained with amphotericin B at 1 mg/kg/day. SCH 56592 has potential for therapy of systemic infections caused by F. solani.
在免疫功能正常的小鼠中，研究了唑类抗真菌剂SCH 5692以10至100毫克/千克体重/天的剂量作为茄病镰刀菌引起的全身感染的治疗方法。在静脉感染后1小时开始治疗，并每天持续给药4或13次。生存时间的延长和器官内病菌清除情况取决于SCH 56592治疗的剂量和持续时间，在50和100毫克/千克/天的剂量下效果最佳。所使用的SCH 56592最高剂量（50或100毫克/千克/天）的结果与两性霉素B以1毫克/千克/天给药所获得的结果相当。SCH 56592有治疗茄病镰刀菌引起的全身感染的潜力。
