Pujol I, Guarro J, Gené J, Sala J
Laboratori de Microbiologia, Hospital Universitari Sant Joan de Reus, Spain.
J Antimicrob Chemother. 1997 Feb;39(2):163-7. doi: 10.1093/jac/39.2.163.
The MICs of amphotericin B, miconazole, ketoconazole, flucytosine, itraconazole and fluconazole for 19 isolates of Fusarium oxysporum, 16 Fusarium solani, seven Fusarium verticilliodes, four Fusarium proliferatum, four Fusarium dimerum, three Fusarium equiseti, and one each of the following species: Fusarium graminearum, Fusarium chlamydosporum, Fusarium semitectum, Fusarium avenaceum and Fusarium subglutinans were determined by a broth microdilution method. Thirty-eight of these isolates were of clinical origin and 20 from environmental sources. In general, Fusarium spp. strains showed resistance to all the antifungals tested. However, the most active agent was amphotericin B. Fluconazole and flucytosine were not active against any of the isolates tested. A correlation study of in-vitro testing with in-vivo outcome of amphotericin B of the cases of disseminated fusarium infections published is reported.
采用肉汤微量稀释法测定了两性霉素B、咪康唑、酮康唑、氟胞嘧啶、伊曲康唑和氟康唑对19株尖孢镰刀菌、16株茄病镰刀菌、7株轮状镰刀菌、4株层出镰刀菌、4株双隔镰刀菌、3株木贼镰刀菌以及以下各1株：禾谷镰刀菌、厚垣镰刀菌、半裸镰刀菌、燕麦镰刀菌和胶孢镰刀菌的最低抑菌浓度（MIC）。这些分离株中38株来源于临床，20株来源于环境。总体而言，镰刀菌属菌株对所有测试抗真菌药物均表现出耐药性。然而，最有效的药物是两性霉素B。氟康唑和氟胞嘧啶对任何测试分离株均无活性。报告了已发表的播散性镰刀菌感染病例中两性霉素B体外测试与体内结果的相关性研究。
