评价两性霉素 B 治疗中间型新孢子虫感染中性粒细胞减少症小鼠模型的效果。
Evaluation of antifungal therapy in a neutropenic murine model of Neoscytalidium dimidiatum infection.
机构信息
Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
出版信息
Int J Antimicrob Agents. 2010 Feb;35(2):152-5. doi: 10.1016/j.ijantimicag.2009.09.028. Epub 2009 Dec 14.
We evaluated the efficacy of amphotericin B (1.5mg/kg/day), voriconazole (60mg/kg/day) and posaconazole (60mg/kg/day) in a murine model of systemic infection caused by Neoscytalidium dimidiatum. All the treatments were able to prolong survival and to reduce the tissue burden in the spleen and kidneys of infected mice. Neither voriconazole nor posaconazole improved the results achieved with amphotericin B.
我们评估了两性霉素 B（1.5mg/kg/天）、伏立康唑（60mg/kg/天）和泊沙康唑（60mg/kg/天）在新司替比星引起的系统性感染的小鼠模型中的疗效。所有治疗方法都能够延长感染小鼠的存活时间，并减少脾脏和肾脏中的组织负担。伏立康唑和泊沙康唑都没有改善两性霉素 B 的疗效。
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