Kaufman K A, Bowen J A, Tsai A F, Bluestone J A, Hunt J S, Ober C
Department of Human Genetics, The University of Chicago, IL 60637, USA.
Mol Hum Reprod. 1999 Jan;5(1):84-7. doi: 10.1093/molehr/5.1.84.
In order to elucidate the mechanisms that ensure survival of the allogeneic fetus, we are investigating the expression pattern of genes that are involved in peripheral self-tolerance in tissues at the maternal-fetal interface. Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a negative regulator of T cell activation and may modulate peripheral self-tolerance. Previously, we reported the preferential transmission of maternally-inherited shorter alleles at a 3'-UTR microsatellite locus to liveborn children, but random transmission of paternally-inherited alleles, suggesting that CTLA-4 may be involved in the maintenance of tolerance at the maternal-fetal interface. In this report, we demonstrate that CTLA-4 mRNA and protein are indeed expressed in fetal tissues at the maternal-fetal interface throughout gestation.
为了阐明确保同种异体胎儿存活的机制，我们正在研究参与母胎界面组织外周自身耐受的基因的表达模式。细胞毒性T淋巴细胞相关蛋白4（CTLA-4）是T细胞活化的负调节因子，可能调节外周自身耐受。此前，我们报道了在一个3'-UTR微卫星位点上，母系遗传的较短等位基因优先传递给活产婴儿，而父系遗传的等位基因则随机传递，这表明CTLA-4可能参与维持母胎界面的耐受性。在本报告中，我们证明CTLA-4 mRNA和蛋白在整个妊娠期母胎界面的胎儿组织中均有表达。
