Linman J W, Bagby C
Nouv Rev Fr Hematol Blood Cells. 1976;17(1-2):11-31. doi: 10.1007/978-3-642-66312-3_2.
The clinical and laboratory features of the stages in the evolution of acute nonlymphocytic leukemia are reviewed. Based on a retrospective analysis of 34 patients who died with an acute myelomonoblastic leukemia, the "preleukemic syndrome" has been shown to display a clinical picture sufficiently specific to permit its recognition prospectively (i.e., before the development of overt leukemia). The results to date of a variety of prospective studies are reviewed, and the approach(es) to the management of these cases is considered.
本文回顾了急性非淋巴细胞白血病演变各阶段的临床和实验室特征。基于对34例死于急性粒单核细胞白血病患者的回顾性分析，已证明“白血病前期综合征”具有足够特异的临床表现，从而能够在出现明显白血病之前进行前瞻性识别。本文回顾了各种前瞻性研究的最新结果，并探讨了这些病例的处理方法。
