Aström A K, Jin D, Imamura T, Röijer E, Rosenzweig B, Miyazono K, ten Dijke P, Stenman G
Laboratory of Cancer Genetics, Department of Pathology, Göteborg University, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Mamm Genome. 1999 Mar;10(3):299-302. doi: 10.1007/s003359900990.
Bone morphogenetic proteins (BMPs) are members of the TGF-beta superfamily that play a pivotal role in bone formation during embryogenesis and fracture repair. BMP signaling occurs via hetero-oligomeric serine/threonine kinase complexes of BMP type I (BMPR-IA or BMPR-IB) and type II receptors (BMPR-II). BMPR-IA and IB are closely related receptors, with sequence differences conserved between different species, suggesting that they serve distinct functions. Here we report the cDNA cloning of human BMPR1B and the chromosomal localization of all three BMPR genes. Using somatic cell hybrid and FISH analyses, the BMPR1A, BMPR1B, and BMPR2 genes were assigned to 10q23, 4q22-24, and 2q33-34, respectively. A processed BMPR1A pseudogene was mapped to 6q23.
骨形态发生蛋白（BMPs）是转化生长因子-β超家族的成员，在胚胎发育和骨折修复过程中的骨形成中起关键作用。BMP信号通过BMP I型（BMPR-IA或BMPR-IB）和II型受体（BMPR-II）的异源寡聚丝氨酸/苏氨酸激酶复合物发生。BMPR-IA和IB是密切相关的受体，不同物种之间的序列差异保守，表明它们具有不同的功能。在此，我们报告了人类BMPR1B的cDNA克隆以及所有三个BMPR基因的染色体定位。使用体细胞杂交和荧光原位杂交分析，BMPR1A、BMPR1B和BMPR2基因分别定位于10q23、4q22-24和2q33-34。一个加工过的BMPR1A假基因定位于6q23。
