Brooks G F, Ingwer I
J Infect Dis. 1978 Sep;138(3):333-9. doi: 10.1093/infdis/138.3.333.
This report concerns the relationships between patients' uncomplicated genital infections due to Neisseria gonorrhoeae and the bactericidal activity of their sera against their infecting organisms. Forty isolates of N. gonorrhoeae and 91 serum samples were obtained from 23 patients with their first or repeated gonococcal infections. Of 32 sera obtained at the time of infection, 14 (44%) were bactericidal for the infecting strains. Of convalescent-phase sera from 27 infections, 12 (44%) were bactericidal; 22%-33% of convalescent-phase sera had increased bactericidal activity when compared with acute-phase sera or sera obtained before infection. Eleven patients developed 17 new infections after sera and negative cultures were obtained; in six (35%) the previously obtained sera were bactericidal but did not prevent infection.
本报告涉及因淋病奈瑟菌引起的患者单纯性生殖器感染与其血清对感染菌的杀菌活性之间的关系。从23例初次或反复感染淋球菌的患者中获取了40株淋病奈瑟菌和91份血清样本。在感染时采集的32份血清中，14份（44%）对感染菌株具有杀菌作用。在27次感染的恢复期血清中，12份（44%）具有杀菌作用；与急性期血清或感染前获得的血清相比，22%-33%的恢复期血清杀菌活性有所增强。在获得血清和阴性培养结果后，11名患者发生了17次新感染；其中6例（35%）先前获得的血清具有杀菌作用，但未能预防感染。
