Kasper D L, Rice P A, McCormick W M
J Infect Dis. 1977 Feb;135(2):243-51. doi: 10.1093/infdis/135.2.243.
An assay of bactericidial antibody has been developed to study the host response to infection with Neisseria gonorrhoeae. This test for antibody was performed on the sera of women who were exposed to N. gonorrhoeae but who did not become infected, of patients with various types of genital infection with N. gonorrhoeae, and of a small number of individuals with no history of gonorrhea. Antibody was found in the sera of less than 31% of men and women with uncomplicated gonococcal infection. Prolonged mucosal infection with the gonococcus (greater than 33 days) correlated with the presence of bactericidal antibody. Bactericidal antibody was not detected in 95% of the specimens of acute-phase serum obtained from women with gonococcal pelvic inflammatory disease. The convalescent-phase sera of 70% of women with clinically severe pelvic inflammatory disease showed a rise in titer of bactericidal antibody to the infecting strain of N. gonorrhoeae, whereas only 11% of the convalescent-phase sera of women with mild or moderately severe disease showed a similar rise.
已开发出一种杀菌抗体检测方法，用于研究宿主对淋病奈瑟菌感染的反应。该抗体检测在接触过淋病奈瑟菌但未被感染的女性血清、患有各种类型淋病奈瑟菌生殖器感染的患者血清以及少数无淋病病史的个体血清上进行。在无并发症淋病感染的男性和女性中，不到31%的血清中发现了抗体。淋球菌长期黏膜感染（超过33天）与杀菌抗体的存在相关。从患有淋菌性盆腔炎的女性获得的急性期血清标本中，95%未检测到杀菌抗体。70%临床症状严重的盆腔炎女性恢复期血清显示，针对感染淋病奈瑟菌菌株的杀菌抗体滴度升高，而症状轻微或中度严重的女性恢复期血清中只有11%显示出类似升高。
