Hyman A L, Kadowitz P J, Lands W E, Crawford C G, Fried J, Barton J
Proc Natl Acad Sci U S A. 1978 Jul;75(7):3522-6. doi: 10.1073/pnas.75.7.3522.
The effects of a recently synthesized, stable prostacyclin (PGI2) analog, 13,14-dehydro-PGI2 methyl ester, and authentic PGI2 and several other prostanoids on the coronary circulation were investigated in the intact dog by using a new technique to measure coronary sinus blood flow. The PGI2 analog, PGI2, and prostaglandin (PG) E2 and D2 each increased coronary sinus blood flow in a dose-related fashion when injected into the left coronary artery. The analog and PGE2 had similar vasodilator activity while PGI2 was slightly more potent. PGD2 was a moderately active coronary vasodilator whereas PGF2alpha was inactive. The coronary vasodilator effects of PGI2, its analog, PGE2, and PGD2 occurred at doses that had little effect on aortic pressure, left ventricular pressure and its first derivative, or on cardiac output and heart rate. The prostaglandin precursor arachidonic acid and the endoperoxide intermediate PGH2 both increased coronary sinus blood flow in a dose-dependent manner. The effects of arachidonic acid were inhibited by indomethacin. These data show that PGE2, PGI2, and a stable PGI2 analog are potent vasodilators in the canine coronary vascular bed and suggest that the vasodilator effects of arachidonic acid and PGH2 may be due to the formation of PGE2, PGD2, or PGI2 in the dog heart.
利用一种测量冠状窦血流量的新技术，在完整的犬身上研究了一种新合成的稳定前列环素（PGI2）类似物13,14-脱氢-PGI2甲酯、天然PGI2以及其他几种前列腺素对冠脉循环的影响。当将PGI2类似物、PGI2、前列腺素（PG）E2和D2注入左冠状动脉时，它们均以剂量相关的方式增加冠状窦血流量。该类似物和PGE2具有相似的血管舒张活性，而PGI2的活性稍强。PGD2是一种中度活性的冠脉血管舒张剂，而PGF2α无活性。PGI2及其类似物、PGE2和PGD2的冠脉血管舒张作用发生时的剂量，对主动脉压、左心室压力及其一阶导数、心输出量和心率几乎没有影响。前列腺素前体花生四烯酸和内过氧化物中间体PGH2均以剂量依赖的方式增加冠状窦血流量。花生四烯酸的作用被吲哚美辛抑制。这些数据表明，PGE2、PGI2和一种稳定的PGI2类似物是犬冠脉血管床中的强效血管舒张剂，并提示花生四烯酸和PGH2的血管舒张作用可能是由于犬心脏中形成了PGE2、PGD2或PGI2。
