Weir E K, Reeves J T, Droegemueller W, Grover R F
Prostaglandins. 1975 Mar;9(3):369-76. doi: 10.1016/0090-6980(75)90141-0.
Intramuscular injection of the 15-methyl analogue of prostaglandin F-2alpha (15-ME-PGF-2alpha) is being used to initiate second trimester abortion. The natural prostaglandin F-2alpha (PGF-2alpha) is a known pulmonary pressor agent but there is little information about the cardiovascular effects of the analogue. Consequently, we compared the hemodynamic responses to the two forms in twenty-three anesthetized dogs. Given I.M. or I.V. 15-me-PGF-2alpha produced a greater and more sustained rise in pulmonary arterial pressure than PGF-2alpha. Intramuscular 15-me-PGF-2alpha also elicited a more prolonged increase in pulmonary vascular resistance than prostaglandin F-2alpha given I.M. or I.V. The methyl analogue (I.M. or I.V.) causes a greater initial fall in systemic arterial oxygen tension and cardiac output, and a greater increase in systemic resistance than I.M. PGF-2alpha. Breathlessness seen during abortion induced by prostaglandin F-2alpha or its methyl analogue may be caused by acute pulmonary hypertension in addition to bronchoconstriction.
肌肉注射前列腺素F-2α的15-甲基类似物（15-ME-PGF-2α）正被用于引发孕中期流产。天然前列腺素F-2α（PGF-2α）是一种已知的肺血管加压剂，但关于该类似物的心血管效应的信息很少。因此，我们比较了23只麻醉犬对这两种形式的血流动力学反应。肌肉注射或静脉注射15-me-PGF-2α比PGF-2α能使肺动脉压产生更大且更持久的升高。肌肉注射15-me-PGF-2α也比肌肉注射或静脉注射前列腺素F-2α引起更长时间的肺血管阻力增加。甲基类似物（肌肉注射或静脉注射）比肌肉注射PGF-2α导致体循环动脉血氧张力和心输出量更大的初始下降，以及体循环阻力更大的增加。除支气管收缩外，前列腺素F-2α或其甲基类似物诱导流产期间出现的呼吸困难可能由急性肺动脉高压引起。
