Woodard G D, McDonald R, Cox J S
J Pharm Sci. 1978 Oct;67(10):1403-5. doi: 10.1002/jps.2600671019.
The interaction of the antiasthmatic drug cromolyn sodium with Mg2+ ions in solution was studied. Selective ion electrode and torsion viscometer measurements were used to establish the degree of interaction. At the concentrations studied, the cromolyn ion had no more affinity for Mg2+ than SO42-. However, thixotropic gels were formed between 4 X 10(-2) M cromolyn sodium and 4 X 10(-4) Mg2+. At lower concentrations of Mg2+, viscosity still increased significantly. However, when the cromolyn concentration was lowered, the increase in viscosity was much less marked.
研究了抗哮喘药物色甘酸钠与溶液中Mg2+离子的相互作用。采用选择性离子电极和扭转粘度计测量来确定相互作用程度。在所研究的浓度下，色甘酸离子对Mg2+的亲和力并不比SO42-更强。然而，在4×10(-2)M色甘酸钠和4×10(-4)Mg2+之间形成了触变凝胶。在较低的Mg2+浓度下，粘度仍显著增加。然而，当色甘酸钠浓度降低时，粘度的增加就不那么明显了。
