Mertz D P, Ksochnick R, Wilk G
Res Exp Med (Berl). 1976 Nov 25;169(1):21-8. doi: 10.1007/BF01851336.
The renal excretion of manganese is investigated for different urine flow rates in adults of both sexes with normal and disturbed kidney function. Mn is determined by emission spectral analysis. During antidiuresis with a mean urine flow rate of 0,97 +/- 0,66 ml/min (SD) the average excretion of Mn is 11,4 +/- 19,4 ng/min for 1,73 m2 body surface area. With an indifferent urine flow (4,43 +/- 2,11 ml/min) the average Mn excretion is 13,5 +/- 19,3 ng/min. For this type of diuresis Mn excretion and urine flow rate are slightly positively correlated. A further increase in urinary excretion of Mn is observed during osmotic diuresis. In this case 160,6 +/- 180,5 ng Mn/min are eliminated for an urine production of 22,2 +/- 6,8 ml/min. The difference of the mean excretion values is highly significant (P less than 0,01) between indifferent urine flow and osmotic diuresis, insignificant between antidiuresis and indifferent urine flow, and significant (P less than 0,01) between antidiuresis and osmotic diuresis. Down to a clearance value for inulin of less than 30 ml/min and for PAH of less than 200 ml/min and 1,73 m2 body surface area, the Mn excretion is largely independent of the renal hemodynamics.
研究了不同尿流率情况下，肾功能正常和异常的成年男女锰的肾排泄情况。锰通过发射光谱分析测定。在平均尿流率为0.97±0.66毫升/分钟（标准差）的抗利尿期，对于1.73平方米的体表面积，锰的平均排泄量为11.4±19.4纳克/分钟。在等渗尿流（4.43±2.11毫升/分钟）时，锰的平均排泄量为13.5±19.3纳克/分钟。对于这种类型的利尿，锰排泄与尿流率呈轻度正相关。在渗透性利尿期间，观察到锰的尿排泄进一步增加。在这种情况下，尿量为22.2±6.8毫升/分钟时，锰的排泄量为160.6±180.5纳克/分钟。等渗尿流与渗透性利尿之间平均排泄值的差异高度显著（P<0.01），抗利尿期与等渗尿流之间差异不显著，抗利尿期与渗透性利尿之间差异显著（P<0.01）。当菊粉清除率低于30毫升/分钟、对氨基马尿酸清除率低于200毫升/分钟且体表面积为1.73平方米时，锰的排泄在很大程度上与肾血流动力学无关。
