[Conditions affecting renal excretion of silver by humans. Studies on metabolism of trace elements. VIII].

The renal excretion of silver was investigated in adult experimental persons of both sexes with normal or variously decreased kidney functions. Silver was measured by emission spectrum analysis. With an indifferent urinary flow of 4.71 plus or minus 2.5 (mean value with standard deviation) ml/min, the mean Ag-excretion was 0.653 plus or minus 0.432 ng/min for a standard 1.73 m2 body surface area. An apparent small increase in the Ag-excretion with increased rate of urine flow could not be statistically confirmed. The widely different Ag-excretion between individuals showed no dependence on the state of diuresis, or on kidney haemodynamic factors down to a decreased inulin clearance of less than 40 ml/min, and a decrease of the PAH clearance to values less than 200 ml/min.