Schubert G E, Durst J, Rahmer H
Res Exp Med (Berl). 1976 Dec 30;169(2):155-67. doi: 10.1007/BF01851176.
Studies on 15 adult rabbits revealed that after removing a 3 hours lasting tourniquet of the left hind limb, the average survival time is 3,6 hours, whereas after a tourniquet lasting 4 hours animals die on the average within 22,8 hours in tourniquet shock. The maximum of interstitial edema and myolysis - estimated by light microscopy - was reached in the ischemic muscles of the hind leg after a 3-6 hours period of recirculation. Extraordinary strong muscle lesions regulary were found in the adductor. In all animals shock lungs could be demonstrated in which hyaline membranes were absent however. 54% of all animals partly showed extensive necroses of liver epithelial cells. Necrosis of cardiac muscle fibres were found in one animal only. In the kidneys merely slight degenerative lesions were identified in the thick descending and ascending limb of Henle's loops, kidneys of longer surviving animals contained many casts.
对15只成年兔子的研究表明，在去除左后肢持续3小时的止血带后，平均存活时间为3.6小时，而在止血带持续4小时后，动物在止血带休克中平均在22.8小时内死亡。再灌注3 - 6小时后，通过光学显微镜估计，后腿缺血肌肉中的间质水肿和肌溶解达到最大值。在内收肌中经常发现异常严重的肌肉损伤。在所有动物中均发现有休克肺，但无透明膜。所有动物中有54%部分显示肝上皮细胞广泛坏死。仅在一只动物中发现心肌纤维坏死。在肾脏中，仅在亨氏袢的厚降支和升支中发现轻微的退行性病变，存活时间较长的动物的肾脏中有许多管型。
