Von Der Lippe G
Scand J Gastroenterol. 1976;11(7):683-8.
Subtotal pancreatectomy in the rat was performed by a new method. Except for a small remnant along the splenal hilus, the gland was completely removed. Exocrine pancreatic insufficiency was confirmed by fat and nitrogen malabsorption. A moderate diabetes mellitus was seen. Insulin substitution or diet restriction was unnecessary. The absorption of vitamin B12 after oral administration of 10 ng 57CoB12 was 5.0 +/- 0.2 (ng 57CoB12 +/- S.E.M.) in unoperated rats and 5.1 +/- 0.1 in pancreatectomized rats (p greater than 0.5). Pancreatic extract (PE) (100 mg) increased the absorption of 57CoB12 in unoperated rats (p less than 0.01), but not in pancreatectomized rats (p greater than 0.2). PE (300 mg) reduced the absorption in unoperated rats (p less than 0.01). The results indicate that an optimal amount of pancreatic secretion may stimulate the absorption of vitamin B12.
采用一种新方法对大鼠进行了胰腺次全切除术。除脾门处有一小部分残留外，胰腺被完全切除。通过脂肪和氮吸收不良证实存在外分泌性胰腺功能不全。出现了中度糖尿病。无需胰岛素替代或饮食限制。未手术大鼠口服10 ng 57CoB12后维生素B12的吸收量为5.0±0.2（ng 57CoB12±标准误），胰腺切除大鼠为5.1±0.1（p＞0.5）。胰腺提取物（PE）（100 mg）可增加未手术大鼠57CoB12的吸收（p＜0.01），但对胰腺切除大鼠无此作用（p＞0.2）。PE（300 mg）可降低未手术大鼠的吸收（p＜0.01）。结果表明，适量的胰腺分泌可能会刺激维生素B12的吸收。
