Ohnhaus E E, Beveridge T
Schweiz Med Wochenschr. 1976 Oct 2;106(40):1365-6.
Collagen-induced platelet aggregation was investigated in healthy volunteers under well defined experimental conditions. The Born aggregometer was used and the two parameters studied were the maximum amount and velocity of aggregation. Under these experimental conditions no significant differences in measurements on 3 consecutive days were found. In addition, identical results were obtained in the same volunteers 4 and 8 weeks following the first experimental period. This experimental procedure was therefore used to test a new nonsteroid anti-inflammatory agent, RU 43-715, for its effect on platelet aggregation. Furthermore, a controlled crossover study using 3 different substances was performed. In the light of the results in the present study, controlled studies on platelet aggregation can be performed even over on even longer period of time under the experimental conditions described.
在明确界定的实验条件下，对健康志愿者的胶原诱导血小板聚集情况进行了研究。使用了博恩血小板聚集仪，所研究的两个参数是聚集的最大量和速度。在这些实验条件下，连续3天的测量未发现显著差异。此外，在第一个实验期后的4周和8周，同一志愿者获得了相同的结果。因此，该实验程序被用于测试一种新的非甾体抗炎药RU 43-715对血小板聚集的影响。此外，还进行了一项使用3种不同物质的对照交叉研究。根据本研究的结果，在所述实验条件下，甚至可以在更长的时间内进行血小板聚集的对照研究。
