Sirover M A, Loeb L A
Science. 1976 Dec 24;194(4272):1434-6. doi: 10.1126/science.1006310.
Thirty-one metal salts have been tested for their ability to affect the accuracy of DNA synthesis in vitro. All ten salts of metal carcinogens decreased the fidelity of DNA synthesis. Of the three metals which beforehand were considered to be possible mutagens or carcinogens, only one decreased fidelity. In contrast, 17 noncarcinogenic metal salts did not affect fidelity even when present at concentrations that were clearly inhibitory.
已经对31种金属盐影响体外DNA合成准确性的能力进行了测试。所有十种金属致癌物的盐都降低了DNA合成的保真度。在预先被认为可能是诱变剂或致癌物的三种金属中，只有一种降低了保真度。相比之下，17种非致癌金属盐即使在明显具有抑制作用的浓度下也不会影响保真度。
