Bamber A I, Neal T J
Department of Medical Microbiology, Royal Liverpool University Hospital.
J Hosp Infect. 1999 Feb;41(2):107-9. doi: 10.1016/s0195-6701(99)90047-6.
Triclosan is widely used to reduce skin colonization with staphylococci and is incorporated into methicillin-resistant Staphylococcus aureus (MRSA) eradication regimes. Using an agar dilution method, the minimum inhibitory concentration (MIC) to triclosan was determined for 186 isolates of MRSA and methicillin sensitive Staphylococcus aureus (MSSA). Fourteen isolates (7.5%) were detected with a MIC > or = 1.0 part per million (ppm). There was no significant difference between the incidence of triclosan resistance in strains of MSSA and MRSA. None of 16 strains of MRSA which exhibited low-level mupirocin resistance had MIC's > or = 1.0 ppm. Increased MIC's of staphylococci to triclosan may contribute to treatment failure when used to eradicate staphylococcal carriage. We suggest that routine susceptibility testing of staphylococci against triclosan might now be indicated.
三氯生被广泛用于减少葡萄球菌在皮肤上的定植，并被纳入耐甲氧西林金黄色葡萄球菌（MRSA）根除方案中。采用琼脂稀释法，测定了186株MRSA和甲氧西林敏感金黄色葡萄球菌（MSSA）对三氯生的最低抑菌浓度（MIC）。检测到14株（7.5%）的MIC≥1.0百万分之一（ppm）。MSSA和MRSA菌株对三氯生的耐药发生率无显著差异。16株表现出低水平莫匹罗星耐药的MRSA菌株中，无一株的MIC≥1.0 ppm。当用于根除葡萄球菌携带时，葡萄球菌对三氯生的MIC增加可能导致治疗失败。我们建议现在可能需要对葡萄球菌进行常规的三氯生药敏试验。
