Court E L
Haematology Department, Princess Margaret Hospital, Wiltshire, England, UK.
Br J Biomed Sci. 1997 Dec;54(4):287-98.
The pathogenesis of the lupus anticoagulant (LA) has been the focus of much research over the past decade, and a plethora of laboratory tests have been developed to detect it. This essay reviews the nature of LA and its pathogenesis, and a number of approaches employed in its diagnosis. These range from well established tests such as the kaolin clotting time (KCT), activated partial thromboplastin time (APTT) and tissue thromboplastin inhibition test (TTI), to the 'newer' tests such as the dilute Russell's viper venom time (DRVVT) and more recent snake venom tests such as the textarin/ecarin ratio and Taipan snake venom time (TSVT). The criteria for diagnosis are discussed, including pre-analytical variables such as sample preparation, and the effects of therapeutic anticoagulants used to treat thrombotic manifestations of the syndrome or an underlying disease process.
过去十年间，狼疮抗凝物（LA）的发病机制一直是大量研究的焦点，并且已经开发出大量实验室检测方法来检测它。本文综述了LA的性质及其发病机制，以及用于其诊断的多种方法。这些方法涵盖了诸如高岭土凝血时间（KCT）、活化部分凝血活酶时间（APTT）和组织凝血活酶抑制试验（TTI）等成熟的检测方法，到诸如稀释蝰蛇毒时间（DRVVT）等“较新”的检测方法，以及诸如泰加林/依卡凝血活酶比值和太攀蛇毒时间（TSVT）等更新的蛇毒检测方法。文中讨论了诊断标准，包括诸如样本制备等分析前变量，以及用于治疗该综合征血栓形成表现或潜在疾病过程的治疗性抗凝剂的影响。
