Vegelin A L, van Vught A J, Wolfs T F, Kimpen J L, Geelen S P
Afd. Algemene Kindergeneeskunde en Infectieziekten, Wilhelmina Kinderziekenhuis, Utrecht.
Ned Tijdschr Geneeskd. 1998 Dec 5;142(49):2657-60.
Four infants, three girls aged 4 weeks, 2.5 months and 3 months, and a boy aged 2 months, were hospitalized because of severe respiratory distress. Apnoea spells with bradycardia and hypoxia were seen in two of the patients, one showing convulsions as well, and bronchopneumonia in the other two, of whom one eventually died. All suffered from pertussis. During outbreaks of pertussis, infants less than 6 months of age are at highest risk for severe disease. In this age group, however, the clinical signs of pertussis are often atypical. Classical symptoms such as paroxysms of cough and loud whoops may be absent while feeding problems, apnoea, cyanosis and bradycardia may be present. For infants younger than 6 months with signs indicating pertussis hospitalization is indicated. In the current vaccination schedule in the Netherlands infants are vaccinated at 3, 4, 5 and 11 months of age. Starting in 1999 the first vaccination will be administered at the age of 2 months.
四名婴儿因严重呼吸窘迫住院，其中三名女孩分别为4周、2.5个月和3个月大，一名男孩为2个月大。两名患者出现呼吸暂停伴心动过缓和缺氧，其中一名还出现惊厥，另外两名患有支气管肺炎，其中一名最终死亡。所有患儿均患有百日咳。在百日咳暴发期间，6个月以下婴儿患重症的风险最高。然而，在这个年龄组中，百日咳的临床症状往往不典型。可能没有典型症状，如阵发性咳嗽和剧烈哮吼，而可能出现喂养问题、呼吸暂停、发绀和心动过缓。对于有百日咳迹象的6个月以下婴儿，建议住院治疗。在荷兰目前的疫苗接种计划中，婴儿在3、4、5和11个月大时接种疫苗。从1999年开始，首次接种将在2个月大时进行。
