Köchli C, Wendland T, Frutig K, Grunow R, Merlin S, Pichler W J
Institute of Immunology and Allergology, Inselspital Bern, Switzerland.
Immunol Lett. 1999 Feb;65(3):197-201. doi: 10.1016/s0165-2478(98)00107-2.
The expression of CD80 and CD86 costimulatory molecules, typical for antigen presenting cells (APC), was measured on circulating T cells of 20 HIV-infected individuals and of 11 HIV-negative healthy controls. The CD80 and CD86 molecules were present on both circulating T subsets of HIV-infected individuals (mean of CD80 expression within CD4+ T cells [CD80/CD4]: 5.0%; and CD86/CD4: 2.6%; CD80/CD8 4.1% and CD86/CD8: 2.7%) and were associated with HLA-DR expression. Some CD80 and CD86 expression was also found in normal controls, and only the expression of CD86 was significantly (P < 0.05) increased on CD4 + and CD8 + T cells of HIV-infected individuals. The expression of CD28 was decreased on T cells of HIV-infected individuals and was negatively correlated to the expression of HLA-DR and CD86 (mean CD28 within CD3+T cells: HIV+ 29.5%, HIV - 67.6%; correlation coefficient, - 0.75 and - 0.71, respectively). The more the disease proceeds, the less CD28 and the more DR and CD86 are found on circulating T cells. This suggests that during HIV infection T cells themselves develop an antigen presenting phenotype by upregulating expression of HLA-DR, CD86 and CD80 molecules.
在20名HIV感染者和11名HIV阴性健康对照者的循环T细胞上，检测了抗原呈递细胞（APC）典型的共刺激分子CD80和CD86的表达。CD80和CD86分子存在于HIV感染者的两个循环T亚群中（CD4 + T细胞内CD80表达的平均值[CD80/CD4]：5.0%；CD86/CD4：2.6%；CD80/CD8 4.1%，CD86/CD8：2.7%），且与HLA-DR表达相关。在正常对照中也发现了一些CD80和CD86的表达，仅HIV感染者的CD4 +和CD8 + T细胞上CD86的表达显著增加（P < 0.05）。HIV感染者T细胞上CD28的表达降低，且与HLA-DR和CD86的表达呈负相关（CD3+T细胞内CD28的平均值：HIV+ 29.5%，HIV - 67.6%；相关系数分别为 - 0.75和 - 0.71）。疾病进展越严重，循环T细胞上发现的CD28越少，DR和CD86越多。这表明在HIV感染期间，T细胞自身通过上调HLA-DR、CD86和CD80分子的表达而发展出一种抗原呈递表型。
