肿瘤坏死因子-α的高产等位基因是严重普马拉病毒引起的流行性肾病易感性主要组织相容性复合体单倍型的一部分。
High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe puumala virus-induced nephropathia epidemica.
作者信息
Kanerva M, Vaheri A, Mustonen J, Partanen J
机构信息
Haartman Institute, Department of Virology, University of Helsinki, Finland.
出版信息
Scand J Infect Dis. 1998;30(5):532-4. doi: 10.1080/00365549850161629.
PMID:10066063
Abstract
The biallelic polymorphisms in the tumour necrosis factor-alpha (TNF-alpha) gene promoter region were studied in patients with nephropathia epidemica (NE). The rarer TNF2 allele, associated with a high TNF-alpha producer phenotype, was more frequently found in hospitalized NE patients (42%) than in healthy controls (15%; p=0.0064). The putative role of TNF2 as an independent risk factor for NE is discussed.
摘要
对流行性肾病（NE）患者肿瘤坏死因子-α（TNF-α）基因启动子区域的双等位基因多态性进行了研究。与高TNF-α产生者表型相关的较罕见的TNF2等位基因，在住院的NE患者中（42%）比在健康对照者中（15%；p=0.0064）更频繁地被发现。文中讨论了TNF2作为NE独立危险因素的假定作用。
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