Kanerva M, Vaheri A, Mustonen J, Partanen J
Haartman Institute, Department of Virology, University of Helsinki, Finland.
Scand J Infect Dis. 1998;30(5):532-4. doi: 10.1080/00365549850161629.
The biallelic polymorphisms in the tumour necrosis factor-alpha (TNF-alpha) gene promoter region were studied in patients with nephropathia epidemica (NE). The rarer TNF2 allele, associated with a high TNF-alpha producer phenotype, was more frequently found in hospitalized NE patients (42%) than in healthy controls (15%; p=0.0064). The putative role of TNF2 as an independent risk factor for NE is discussed.
对流行性肾病（NE）患者肿瘤坏死因子-α（TNF-α）基因启动子区域的双等位基因多态性进行了研究。与高TNF-α产生者表型相关的较罕见的TNF2等位基因，在住院的NE患者中（42%）比在健康对照者中（15%；p=0.0064）更频繁地被发现。文中讨论了TNF2作为NE独立危险因素的假定作用。
