Department of Virology, Haartman Institute, P.O. Box 21, University of Helsinki, Finland.
Nat Rev Microbiol. 2013 Aug;11(8):539-50. doi: 10.1038/nrmicro3066.
Hantaviruses are negative-sense single-stranded RNA viruses that infect many species of rodents, shrews, moles and bats. Infection in these reservoir hosts is almost asymptomatic, but some rodent-borne hantaviruses also infect humans, causing either haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). In this Review, we discuss the basic molecular properties and cell biology of hantaviruses and offer an overview of virus-induced pathology, in particular vascular leakage and immunopathology.
汉坦病毒是感染多种啮齿类动物、鼩鼱、鼹鼠和蝙蝠的负义单链 RNA 病毒。在这些储存宿主中，感染几乎无症状，但一些啮齿动物传播的汉坦病毒也感染人类，导致肾综合征出血热 (HFRS) 或汉坦病毒心肺综合征 (HCPS)。在这篇综述中，我们讨论了汉坦病毒的基本分子特性和细胞生物学，并概述了病毒诱导的病理学，特别是血管渗漏和免疫病理学。
