Mustonen J, Partanen J, Kanerva M, Pietilä K, Vapalahti O, Pasternack A, Vaheri A
Medical School, University of Tampere and Tampere University Hospital, Finland.
Scand J Immunol. 1998 Mar;47(3):277-9. doi: 10.1046/j.1365-3083.1998.00302.x.
Both the severe course of nephropathia epidemica (NE) caused by Puumala hantavirus, and the fast progression of human immunodeficiency virus (HIV) disease, are associated with the HLA B8 DRB1*0301 haplotype. As HLA B27, on the contrary, is associated with the slow progression of HIV disease, we wanted to test whether the same is true for NE. Only six (8%) NE patients, half the figure expected, had the HLA B27 allele in 74 randomly selected hospital-treated patients. All six had a benign overall clinical course of NE; none had any severe complications, the severity of renal failure was also mild, and the treatment time at the hospital was half that needed for HLA B27- patients (P = 0.004). Patients who were HLA B27 had maximal blood leucocyte count > 10.000 x 10(9)/L (P = 0.020) more often, probably reflecting differences in immune response. Thus, similar HLA associations can be found in both HIV infection and NE caused by Puumala virus.
由普马拉汉坦病毒引起的流行性肾病（NE）的严重病程以及人类免疫缺陷病毒（HIV）疾病的快速进展，均与HLA B8 DRB1*0301单倍型相关。相反，HLA B27与HIV疾病的缓慢进展相关，我们想测试这对于NE是否同样成立。在74例随机选择的住院治疗患者中，只有6例（8%）NE患者携带HLA B27等位基因，这一数字仅为预期数字的一半。所有6例患者的NE总体临床病程均为良性；均无任何严重并发症，肾衰竭的严重程度也较轻，且在医院的治疗时间仅为非HLA B27患者所需时间的一半（P = 0.004）。携带HLA B27的患者白细胞计数最大值> 10.000×10⁹/L（P = 0.020）的情况更为常见，这可能反映了免疫反应的差异。因此，在HIV感染和普马拉病毒引起的NE中均可发现类似的HLA关联。
