Morano K A, Liu P C, Thiele D J
Department of Biological Chemistry, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109-0606, USA.
Curr Opin Microbiol. 1998 Apr;1(2):197-203. doi: 10.1016/s1369-5274(98)80011-8.
Recent studies have shed new light on the complexities of the heat shock response in yeast. Multiple pathways for transcriptional induction of both classic and novel heat shock proteins are emerging together with a more detailed understanding of the interactions between protein chaperones and their physiological targets. New roles for heat shock proteins in defense and recovery from the impacts of thermal stress on critical cellular processes have expanded our understanding of these elaborate and ubiquitous proteins.
最近的研究为酵母热休克反应的复杂性带来了新的认识。经典和新型热休克蛋白转录诱导的多种途径正在显现，同时对蛋白质伴侣与其生理靶点之间相互作用的理解也更加详细。热休克蛋白在抵御热应激对关键细胞过程的影响以及从中恢复过程中的新作用，扩展了我们对这些复杂且普遍存在的蛋白质的理解。
