Müller A, Stein G, Lehmann G, Hein G
Rheumatologie und Osteologie, Klinik für Innere Medizin IV, Rheumalabor, Erlanger Allee 101, 07740 JENA, Germany.
Eur J Med Res. 1999 Feb 25;4(2):78-84.
The renal bone disease which develops in chronic renal failure (CRF) is not an uniform disorder. Histomorphometry is accepted to be the best method for characterising the state of disease. The purpose of this study was to evaluate the suitability of pyridinium crosslinks in serum and urine as indicators of bone degradation processes. Patients with CRF had significantly higher Pyridinoline (Pyd) and Deoxypyridinoline (Dpyd) levels in serum and urine compared to normal controls except the urinary excretion in the subgroup of glomerulonephritis. A correlation was found between the serum levels of crosslinks and those of both creatinine and parathormone. The Pyd and Dpyd serum levels in patients under dialysis treatment were significantly higher than those of normal controls. With regard to bone turnover urinary crosslink measurements are of minor importance in CRF. In contrast, serum measurements could be helpful in revealing bone resorption both in patients with CRF and those under dialysis treatment.
慢性肾衰竭（CRF）中发生的肾性骨病并非一种统一的病症。组织形态计量学被认为是表征疾病状态的最佳方法。本研究的目的是评估血清和尿液中的吡啶交联物作为骨降解过程指标的适用性。与正常对照组相比，CRF患者血清和尿液中的吡啶啉（Pyd）和脱氧吡啶啉（Dpyd）水平显著更高，但肾小球肾炎亚组的尿排泄情况除外。发现交联物的血清水平与肌酐和甲状旁腺激素的水平之间存在相关性。接受透析治疗的患者的Pyd和Dpyd血清水平显著高于正常对照组。关于骨转换，尿交联物测量在CRF中重要性较小。相比之下，血清测量有助于揭示CRF患者和透析治疗患者的骨吸收情况。
