Duffield T F, Leslie K E, Sandals D, Lissemore K, McBride B W, Lumsden J H, Dick P, Bagg R
University of Guelph, ON, Canada.
J Dairy Sci. 1999 Feb;82(2):272-9. doi: 10.3168/jds.S0022-0302(99)75233-1.
Dry cows and pregnant heifers from 25 farms near Guelph, Ontario, Canada were enrolled in a large double-blind, randomized clinical trial that was designed to evaluate the impact of monensin on energy metabolism, health, and production. A total of 503 cows was given monensin in controlled-release capsules, and 507 were administered placebo capsules 3 wk prior to the expected calving date. The effects of treatment on milk production and milk components at the first three Dairy Herd Improvement (DHI) tests were evaluated using repeated measures analysis of variance. Treatment with monensin increased milk production, but this effect was dependent on body condition score prior to calving. Cows that were classified as thin (score of < or = 3.0) did not have increased production in response to monensin treatment. Cows with fair body condition (score of 3.25 to 3.75) produced significantly more milk at the second DHI test (+0.85 kg), but cows that were fat (score of > or = 4.0) produced significantly more milk than did controls for all three DHI tests (+1.25 kg) in early lactation. Monensin significantly increased projected 305-d milk production in cows from herds at increased risk of ketosis. Treatment with monensin had no significant effect on either milk fat percentage or milk protein percentage.
来自加拿大安大略省圭尔夫市附近25个农场的干奶牛和怀孕小母牛被纳入一项大型双盲随机临床试验，该试验旨在评估莫能菌素对能量代谢、健康和生产性能的影响。共有503头奶牛被投喂含莫能菌素的控释胶囊，507头在预计产犊日期前3周被投喂安慰剂胶囊。使用重复测量方差分析评估处理对前三次奶牛群改良（DHI）测试中牛奶产量和牛奶成分的影响。莫能菌素处理可提高牛奶产量，但这种效果取决于产犊前的体况评分。被归类为瘦（评分≤3.0）的奶牛对莫能菌素处理没有产奶量增加的反应。体况中等（评分3.25至3.75）的奶牛在第二次DHI测试时产奶量显著增加（+0.85千克），但肥胖（评分≥4.0）的奶牛在泌乳早期的所有三次DHI测试中产奶量均显著高于对照组（+1.25千克）。莫能菌素显著提高了酮病风险增加的牛群中奶牛的预计305天牛奶产量。莫能菌素处理对乳脂率或乳蛋白率均无显著影响。
