Duffield T F, Sandals D, Leslie K E, Lissemore K, McBride B W, Lumsden J H, Dick P, Bagg R
Department of Animal and Poultry Science, University of Guelph, ON, Canada.
J Dairy Sci. 1998 Sep;81(9):2354-61. doi: 10.3168/jds.S0022-0302(98)70126-2.
The effects of monensin on the energy metabolism of dairy cows in early lactation were investigated in a large clinical trial that was randomized and double-blinded. A total of 1010 Holstein cows and first lactation heifers were allocated to receive a controlled-release capsule of monensin or a placebo at 3 wk prior to expected calving date. Treatments were randomized across 25 dairy farms located near Guelph, Ontario, Canada. Serum samples obtained at the time of treatment administration and at wk 1, 2, 3, 6, and 9 postcalving were analyzed for beta-hydroxybutyrate, glucose, aspartate aminotransferase, urea, total protein, calcium, and phosphorus. Cows were also assigned a body condition score at the time each sample was obtained. Monensin treatment significantly reduced serum beta-hydroxy-butyrate concentrations at wk 1, 2, and 3 postpartum and significantly raised serum glucose concentrations during wk 1 and 2 of lactation. In addition, monensin treatment significantly reduced the loss of body condition score and decreased serum activity of aspartate aminotransferase during the postpartum period. Concentrations of serum urea were significantly higher during wk 2 and 3 postpartum for the cows that were treated with monensin. Monensin treatment had no effect on the concentrations of calcium, phosphorus, or total protein.
在一项随机双盲大型临床试验中，研究了莫能菌素对初产奶牛能量代谢的影响。共有1010头荷斯坦奶牛和头胎小母牛在预计产犊日期前3周被分配接受莫能菌素控释胶囊或安慰剂。处理在加拿大安大略省圭尔夫附近的25个奶牛场随机进行。在给药时以及产后第1、2、3、6和9周采集血清样本，分析其中的β-羟基丁酸、葡萄糖、天冬氨酸转氨酶、尿素、总蛋白、钙和磷。每次采集样本时，还对奶牛进行体况评分。莫能菌素处理显著降低了产后第1、2和3周时血清β-羟基丁酸的浓度，并在泌乳第1和2周显著提高了血清葡萄糖浓度。此外，莫能菌素处理显著减少了体况评分的下降，并降低了产后期间血清天冬氨酸转氨酶的活性。莫能菌素处理的奶牛在产后第2和3周时血清尿素浓度显著更高。莫能菌素处理对钙、磷或总蛋白的浓度没有影响。
