大肠杆菌突变基因。
Escherichia coli mutator genes.
作者信息
Horst J P, Wu T H, Marinus M G
机构信息
Dept of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, Worcester 01655, USA.
出版信息
Trends Microbiol. 1999 Jan;7(1):29-36. doi: 10.1016/s0966-842x(98)01424-3.
Abstract
The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.
摘要
大肠杆菌突变基因的分离和表征有助于更好地理解DNA复制保真机制，并发现重要的DNA修复途径及其与自发诱变的关系。细胞群体中的突变菌株可能是有益的，因为它们允许在应激期间（如药物暴露）快速选择变体。
Zotero 插件