使用四极杆离子阱中的多级串联质谱（MSn）测定锌（II）-二乙烯三胺-二糖络合物中糖苷键的异头构型。
Determining anomericity of the glycosidic bond in Zn(II)-diethylenetriamine-disaccharide complexes using MSn in a quadrupole ion trap.
作者信息
Gaucher S P, Leary J A
机构信息
Department of Chemistry, University of California, Berkeley 94720, USA.
出版信息
J Am Soc Mass Spectrom. 1999 Mar;10(3):269-72. doi: 10.1016/S1044-0305(98)00149-4.
Zinc-diethylenetriamine (Zn-dien) N-glycoside complexes of four 1,4 and four 1,6 linked disaccharides are prepared. Each reaction mixture is ionized by electrospray and the resulting species [Zn(dien)(disaccharide)-H]+ is allowed to undergo collision-induced dissociation in a quadrupole ion trap. An MS3 analysis is used to differentiate alpha versus beta anomericity of the glycosidic bond in the disaccharide moiety. In addition, the MS2 and MS3 spectra can be used together to determine the linkage position of this glycosidic bond.
制备了四种1,4-连接和四种1,6-连接二糖的锌-二乙烯三胺（Zn-dien）N-糖苷配合物。每个反应混合物通过电喷雾进行离子化，然后使生成的物种[Zn(dien)(二糖)-H]+在四极离子阱中发生碰撞诱导解离。采用MS3分析来区分二糖部分中糖苷键的α型和β型异头物。此外，MS2和MS3光谱可一起用于确定该糖苷键的连接位置。
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