Yang Q, Khoury M J, Sun F, Flanders W D
Division of Birth Defects and Developmental Disabilities, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Epidemiology. 1999 Mar;10(2):167-70.
The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the frequencies of genes are independent in the population. Just as the case-only design requires fewer cases than the case-control design to measure gene-environment interaction, it also requires fewer cases to measure gene-gene interactions.
病例对照设计是在人群中暴露与基因型独立的假设下筛查基因-环境相互作用的一种有效且可行的方法。在本文中，我们表明，在人群中基因频率独立的假设下，病例对照设计也是测量基因-基因相互作用的一种有效且可行的方法。正如病例对照设计在测量基因-环境相互作用时比病例对照设计需要更少的病例一样，它在测量基因-基因相互作用时也需要更少的病例。
